保红坤，男，博士，副研究员，硕士研究生导师，best365体育官网平台中青年骨干教师。

毕业院校：best365体育官网平台

 研究领域：精神疾病/神经退行性疾病发病机制、治疗靶点及其治疗天然小分子药物筛选。

联系方式：baohongkun@ynu.edu.cn

办公地址：昆明市呈贡校区best365体育官网平台

代表论文：

   1. Xingzong Sun^# ; Menghan Qian^# ; Hongliang Li^# ; Lei Wang; Yunjie Zhao; Min Yin*; Lili Dai*; Hongkun Bao*. FKBP5 activates mitophagy by ablating PPAR-γ to shape a benign remyelination environment. Cell Death Disease. 2023, 14(11):736.

2. Dandan Zhang^#; Yue Jia^#; Xingzong Sun^#; Haoran Li; Min Yin; Hongliang Li; Lili Dai; Li Han; Lei Wang; Menghan Qian; Jing Du*; Keming Zhu*; Hongkun Bao*. The Dectin-1 Receptor Signaling Pathway Mediates the Remyelination Effect of Lentinan through Suppression of Neuroinflammation and Conversion of Microglia. Journal of Immunology Research. 2022, 2022:3002304.

3. Hongkun Bao^#*; Haoran Li^#; Yue Jia^#; Yuhuan Xiao; Shaolei Luo; Dandan Zhang; Li Han; Lili Dai; Chunjie Xiao; Lei Feng; Yuan Feng; Yang Yang; Han Wang; Gang Wang; Jing Du*. Ganoderic acid A exerted antidepressant-like action through FXR modulated NLRP3 inflammasome and synaptic activity. Biochemical Pharmacology. 2021, 188:114561.

4. Haoran Li^#; Yuhuan Xiao^#; Li Han^#; Yue Jia; Shaolei Luo; Dandan Zhang; Ling Zhang; Peng Wu; Chunjie Xiao; Weijing Kan; Jing Du^*; Hongkun Bao^*. Ganoderma lucidum polysaccharides ameliorated depression-like behaviors in the chronic social defeat stress depression model via modulation of Dectin-1 and the innate immune system. Brain Research Bulletin. 2021, 171:16-24.

5. Yue Jia^#; Dandan Zhang^#; Haoran Li^#; Shaolei Luo; Yuhuan Xiao; Li Han; Fuchun Zhou; Chuanyue Wang; Lei Feng; Gang Wang; Peng Wu; Chunjie Xiao; Haijing Yu; Jing Du^*; Hongkun Bao^*. Activation of FXR by ganoderic acid A promotes remyelination in multiple sclerosis via anti-inflammation and regeneration mechanism. Biochemical pharmacology. 2021, 185:114422.

6. Yue Jia^#; Dandan Zhang^#; Hua Yin; Haoran Li; Jing Du^*; Hongkun Bao^*. Ganoderic Acid A Attenuates LPS-Induced Neuroinflammation in BV2 Microglia by Activating Farnesoid X Receptor. Neurochemical Research. 2021, 46(7):1725-1736. 

7. Shaolei Luo^#; Yangyang Hou^#; Yaping Zhang^#; Lei Feng; Richard G Hunter; Peixiong Yuan; Yue Jia; Haoran Li; Gang Wang; Husseini K Manji; Bruce S McEwen; Chunjie Xiao; Hongkun Bao^*; Jing Du^*. Bag-1 mediates glucocorticoid receptor trafficking to mitochondria after corticosterone stimulation: Potential role in regulating affective resilience. Journal of Neurochemistry. 2021,158(2):358-372.

8. Yangyang Hou^#; Shaolei Luo^#; Yaping Zhang^#; Yue Jia; Haoran Li; Chunjie Xiao; Hongkun Bao^*; Jing Du^*. Contrasting effects of acute and long-term corticosterone treatment on amyloid-β, beta-secretase 1 expression, and nuclear factor kappa B nuclear translocation. Journal of Integrative Neuroscience. 2019, 30;18(4):393-400.

9. Yue Jia^#; Haoran Li^#; Hongkun Bao^#; Dandan Zhang; Lei Feng; Yuhuan Xiao; Keming Zhu; Yangyang Hou; Shaolei Luo; Yaping Zhang; Le Xiao; Xu Chen; Jiaojiao Zhou; Changming Wang; Gang Wang; Haijing Yu; Chunjie Xiao*; Jing Du*. Cordycepin (3'-deoxyadenosine) promotes remyelination via suppression of neuroinflammation in a cuprizone-induced mouse model of demyelination. International Immunopharmacology. 2019, 75:105777.

10. Hongkun Bao ^#; Lijuan Sun^#; Ying Zhu^#; Pengzhan Ran; Weihong Hu; Keming Zhu; Bai Li; Yangyang Hou; Jun Nie; Tangxin Gao; Liping Shan; Kai Du; Shangyong Zheng; Bingrong Zheng; Chunjie Xiao^*; Jing Du^*. Lentinan produces a robust antidepressant-like effect via enhancing theprefrontal Dectin-1/AMPA receptor signaling pathway. Behavioural brain research. 2017, 317:263-271.

11. Hongkun Bao^#; Pengzhan Ran^#; Lijuan Sun^#; Weihong Hu; Hongliang Li; Chunjie Xiao; Keming Zhu^*; Jing Du^*. Griflola frondosa (GF) produces significant antidepressant effects involving AMPA receptor activation in mice. Pharmaceutical biology. 2017, 55(1): 299-305.

  12. Hongkun Bao^#; Pengzhan Ran^#; Ming Zhu^#; Lijuan Sun; Bai Li; Yangyang Hou; Jun Nie; Liping Shan; Hongliang Li; Shangyong Zheng; Xiufeng Xu; Chunjie Xiao^*; Jing Du^*. The Prefrontal Dectin-1/AMPA Receptor Signaling Pathway Mediates The Robust and Prolonged Antidepressant Effect of Proteo-beta-Glucan from Maitake. Scientific reports. 2016, 6:28395-28395.

（注：#第一作者，*通讯作者）

主持项目：

1. 国家自然科学基金青年基金，82301535，FKBP5通过PPAR-γ调节线粒体自噬抑制NLRP3炎症小体在脱髓鞘中的机制研究，2024-01-2026-12，30万元，主持。

2. 国家自然科学基金地区基金，31860267，Dectin-1受体调节小胶质细胞促进少突胶质前体细胞分化介导髓鞘再生的机制研究，2019-01至2022-12，39万元，主持。

3. 云南省科技厅面上项目，202301AT070109，FKBP5通过PINK1调节线粒体自噬在脱髓鞘中的分子机制研究，2023-06至2026-05，10万元，主持。

4. 云南省科技厅面上项目，202001BB050003，FXR受体调节NLRP3炎症小体和神经可塑性介导的抗抑郁分子机制研究，2020-09至2023-08，10万元，主持。

5. 云南省科技厅青年项目，2019FD136，Dectin-1受体调节小胶质细胞极化介导髓鞘再生的机制研究，2019-07至2022-06，5万元，主持。

6. 入选best365体育官网平台中青年骨干教师培养计划（2018年），2018-05至2021-04，8万元，主持。